Efficacy of high-dose oral erythromycin on enhancement of feeding tolerance in premature neonates
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Abstract:
Objective: Most neonates admitted to neonatal wards do not tolerate sufficient milk. Recently the effect of erythromycin on increasing feeding tolerance in neonates has been studied. In this study the effectiveness of oral, high dose Erythromycin a prokinetic agent was used to enhance feeding tolerance in these neonates. Methods: This prospective randomized controlled clinical trial was conducted on 60 premature neonates with birth weight< 1800 g at Hafez and Namazi hospitals in Shiraz during a 13- month period. Those neonates who did not tolerate milk more than 75 cc/kg/day five days after starting feeding, were chosen for the study. A total of 60 neonates were studied who were divided randomly into two equal groups (control and study), and were similar in sex, birth weight, gestational age, apgar score, route of delivery, oxygen need, type of milk and corticosteroid therapy in the antepartum period. Oral erythromycin (ethyl succinate suspension) was given in a dose of 12.5mg/kg/dose every 6 hours for a maximum of 10 days, or until they tolerated full enteral feeding (150 cc/kg/day). One neonate in the erythromycin group and two neonates in the control group expired during the study. Results: Oral erythromycin was effective on enhancement of feeding tolerance in premature neonates with gestational age equal to or more than 32 weeks (p= 0.031) and lead to earlier discharge of these neonates from hospital (p= 0.003). Also oral erythromycin was relatively effective in enhancement of feeding and early discharge of neonates with birth weight equal to or greater than 1500 g. Erythromycin was not effective for neonates less than 32 weeks of age (very preterm). In this study, no adverse effects (necrotizing enterocolitis, sepsis, O2 dependency, patent ductus arteriosus, high-dose positive stool culture or prolonged QT interval) were observed following erythromycin usage. Conclusion: High-dose oral erythromycin in premature neonates of gestational age equal to or greater than 32 weeks with feeding intolerance is effective for increasing feeding tolerance and earlier hospital discharge. However, routine use is not suggested.
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efficacy of high-dose oral erythromycin on enhancement of feeding tolerance in premature neonates
objective: most neonates admitted to neonatal wards do not tolerate sufficient milk. recently the effect of erythromycin on increasing feeding tolerance in neonates has been studied. in this study the effectiveness of oral, high dose erythromycin a prokinetic agent was used to enhance feeding tolerance in these neonates. methods: this prospective randomized controlled clinical trial was con...
full textInfluence of high-dose oral erythromycin on feeding intolerance in preterm neonates: A randomized controlled trial
Background: Feeding intolerance is a common complication in preterm neonates and is responsible for prolonged hospitalization. This study aimed at assessing the effects of high-dose oral erythromycin on feeding intolerance in preterm infants. Methods: A randomized, double blinded, placebo-controlled trial was performed during 2014 and 2015 (Tehran-Iran). Preterm neonates aged >14 ...
full textThe Efficacy of Oral Erythromycin in Enhancement of Milk Tolerance in Premature Infants: A Randomized Clinical Trial
Background: A great number of premature neonates do not tolerate sufficient milk during the early neonatal period. Objective: To evaluate the effect of oral erythromycin on enhancement of feeding tolerance in preterm newborns. Methods: Sixty preterm neonates intolerant to milk of >75 ml/kg/day during 5 days after the start of feedings, were randomized into a treatment and a control groups. Or...
full textthe efficacy of oral erythromycin in enhancement of milk tolerance in premature infants: a randomized clinical trial
background: a great number of premature neonates do not tolerate sufficient milk during the early neonatal period. objective: to evaluate the effect of oral erythromycin on enhancement of feeding tolerance in preterm newborns. methods: sixty preterm neonates intolerant to milk of >75 ml/kg/day during 5 days after the start of feedings, were randomized into a treatment and a control groups....
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15 صفحه اولMy Resources
Journal title
volume 1 issue 1
pages 14- 19
publication date 2010-01-01
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